产品货号：
Z37134
中文名称：
FLI1抗体
英文名称：
Anti-FLI1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FLI1 Antibody |
| 指标别名 | EWSR2;FLI1;Proto oncogene Fli 1;SIC 1;Transcription factor ERGB |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC |
| 基因名称 | FLI1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human FLI1 |
| 实际分子量 | 51KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Friend leukemia integration 1 transcription factor,also known as Transcription factor ERGB or Proto-oncogene Fli-1 is a protein that in humans is encoded by the human FLI1 gene.The fli1 protooncogene encodes a member of the ETS family of winged helix-turn-helix transcription factors.This gene is mapped to 11q24.3.Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway,blocking erythroid differentiation,activating the Ras pathway,and resulting in massive Epo-independent proliferation of erythroblasts.These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation. |
| Uniprot ID | Q01543 |
| 基因名全称 | Friend leukemia integration 1 transcription factor |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 |
相关搜索：FLI1抗体，FLI1单抗，Anti-FLI1 Antibody